Modern Evaluation of Liquisolid Systems with Varying Amounts of Liquid Phase Prepared Using Two Different Methods

Table 2

Flow properties of the tableting mixtures.

Sample	Simple blending				HR	Spraying				HR
	Flowability	Angle of repose	Angle of slide	CI		Flowability	Angle of repose	Angle of slide	CI
	s/100 g	°	°	%		s/100 g	°	°	%
40%w	102.19 ± 0.36	28.06 ± 1.09	36.00 ± 2.00	16.67	1.20	8.88 ± 0.12	29.38 ± 2.36	28.67 ± 1.15	13.08	1.15
50%w	83.16 ± 0.64	27.29 ± 0.46	38.00 ± 2.00	17.53	1.21	7.54 ± 0.61	28.33 ± 1.22	35.67 ± 0.58	14.89	1.18
60%w	63.63 ± 0.49	30.32 ± 0.35	37.67 ± 2.08	17.58	1.21	6.25 ± 0.23	31.21 ± 1.16	29.33 ± 1.53	13.58	1.16
70%w	65.43 ± 0.41	28.97 ± 1.43	36.67 ± 0.58	17.33	1.21	56.37 ± 0.62	26.70 ± 1.28	35.33 ± 0.58	15.38	1.18
80%w	64.80 ± 4.32	26.43 ± 0.48	36.33 ± 0.58	17.02	1.21	57.90 ± 0.90	28.07 ± 0.46	34.33 ± 0.58	15.28	1.18
90%w	60.90 ± 2.70	27.25 ± 0.47	35.67 ± 0.58	16.85	1.20	5.19 ± 0.01	28.57 ± 0.85	38.33 ± 1.53	16.22	1.19
100%w	4.85 ± 0.42	29.40 ± 0.79	35.67 ± 1.15	16.22	1.19	27.72 ± 0.48	30.70 ± 0.88	34.33 ± 1.53	14.29	1.17
110%w	4.60 ± 0.12	31.51 ± 0.87	33.00 ± 1.00	16.90	1.20	32.81 ± 0.98	21.19 ± 0.53	32.33 ± 0.58	15.15	1.18
120%w	4.14 ± 0.34	27.77 ± 0.52	34.33 ± 2.08	18.75	1.23	30.49 ± 1.59	23.83 ± 2.68	33.00 ± 1.00	13.11	1.15