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BioMed Research International
Volume 2015 (2015), Article ID 613247, 12 pages
Research Article

Electrical Bioimpedance Spectroscopy on Acute Unilateral Stroke Patients: Initial Observations regarding Differences between Sides

1School of Technology and Health, KTH-Royal Institute of Technology, Alfred Nobels Allé 8, 14152 Huddinge, Sweden
2School of Engineering, University of Borås, Allégatan 1, 50190 Borås, Sweden
3Department of Neurology, R54, Karolinska University Hospital, Huddinge Unit, 141 86 Stockholm, Sweden
4Department of Clinical Neuroscience, Neuro-Angiological Research Center, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden
5Department of Clinical Science, Intervention and Technology, Karolinska Institute, 46 141 86 Stockholm, Sweden

Received 11 March 2015; Accepted 18 May 2015

Academic Editor: Nohra Chalouhi

Copyright © 2015 Fernando Seoane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Electrical Bioimpedance Cerebral Monitoring is assessment in real time of health of brain tissue through study of passive dielectric properties of brain. During the last two decades theory and technology have been developed in parallel with animal experiments aiming to confirm feasibility of using bioimpedance-based technology for prompt detection of brain damage. Here, for the first time, we show that electrical bioimpedance measurements for left and right hemispheres are significantly different in acute cases of unilateral stroke within 24 hours from onset. Methods. Electrical BIS measurements have been taken in healthy volunteers and patients suffering from acute stroke within 24 hours of onset. BIS measurements have been obtained using SFB7 bioimpedance spectrometer manufactured by Impedimed ltd. and 4-electrode method. Measurement electrodes, current, and voltage have been placed according to 10–20 EEG system obtaining mutual BIS measurements from 4 different channels situated in pairs symmetrically from the midsagittal line. Obtained BIS data has been analyzed, assessing for symmetries and differences regarding healthy control data. Results. 7 out of 10 patients for Side-2-Side comparisons and 8 out 10 for central/lateral comparison presented values outside the range defined by healthy control group. When combined only 1 of 10 patients exhibited values within the healthy range. Conclusions. If these initial observations are confirmed with more patients, we can foresee emerging of noninvasive monitoring technology for brain damage with the potential to lead to paradigm shift in treatment of brain stroke and traumatic brain damage.