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BioMed Research International
Volume 2015, Article ID 613439, 11 pages
Review Article

Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions

1Chair of Regenerative Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24 Street, 85-092 Bydgoszcz, Poland
2Department of Polymer Technology, Gdansk University of Technology, Narutowicza 11/12 Street, 80-233 Gdansk, Poland
3University of Bydgoszcz, Unii Lubelskiej 4C Street, 85-059 Bydgoszcz, Poland
4Department of Urology, Nicolaus Copernicus Hospital, Batory 17-19 Street, 87-100 Torun, Poland

Received 17 August 2014; Revised 15 November 2014; Accepted 18 November 2014

Academic Editor: Ulrich Kneser

Copyright © 2015 Marta Pokrywczynska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Construction of the urinary bladder de novo using tissue engineering technologies is the “holy grail” of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be bladder acellular matrix (BAM). In this review we determine the most important factors, which may affect biological and physical properties of BAM and its regeneration potential in tissue engineered urinary bladder. We also point out the directions in modification of BAM, which include incorporation of exogenous growth factors into the BAM structure. Finally, we discuss the results of the urinary bladder regeneration with cell seeded BAM.