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BioMed Research International
Volume 2015, Article ID 617143, 6 pages
http://dx.doi.org/10.1155/2015/617143
Research Article

Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma

1Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China
2Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China
3Department of Pathology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China
4Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China

Received 18 May 2015; Revised 14 October 2015; Accepted 19 October 2015

Academic Editor: Monica Cantile

Copyright © 2015 Minzhong Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3α and cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3α was significantly associated with TNM stage in patients with NPC (). NPC patients with positive expression of MIP-3α exhibited shorter median overall survival (OS) and distant metastasis-free survival (DMFS), compared with patients with negative expression (OS: 50.5 months versus 59.0 months, ; DMFS: 50.1 months versus 60.2 months, ). NPC patients with positive expression of cystatin A exhibited shorter median OS, local recurrence-free survival (LRFS), and DMFS, compared with patients with negative expression (OS: 51.1 months versus 60.0 months, ; LRFS: 54.5 months versus 59.5 months, ; DMFS: 52.3 months versus 58.8 months, ). Both MIP-3α and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3α and cystatin A expressions may be valuable prognostic markers in NPC patients.