Organotypic Culture of Breast Tumor Explants as a Multicellular System for the Screening of Natural Compounds with Antineoplastic Potential

Figure 6

Effect of different treatments on the viability of breast cancer explants. Tumor explants were incubated with the bioactive compounds for 48 h and then cell viability was determined using the Alamar Blue assay. Control explants did not receive any treatment. Concentrations of compounds were 100 μg/mL CA and UA, 120 μg/mL RA, and 20 μg/mL TX. The same concentrations were used in the combinations. Results were compared to the untreated control. Values reflect means ± SD. Asterisks () indicate significant statistical differences () compared to control. Pound key (#) indicates significant statistical differences () compared to paclitaxel.

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