Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review

Table 4

Univariate analysis group A and group B patients.

Prognostic factors	Pts’ number	2-year OS
Age
55 years	26	38.4%	0.04
>55 years	38	23.7%
Sex
Male	35	28.6%	n.s.
Female	29	31%
Histology
Anaplastic astrocytoma	21	52.4%	<0.0001
Glioblastoma; Multiforme	43	16.3%
Surgery
Stereotactic biopsy	12	25%	n.s.
Subtotal resection	30	23.3%
Total resection	22	36.6%
Timing TMZ
Adjuvant	31	29%	n.s.
Concomitant/adjuvant	33	30%
RT total dose
≥60 Gy	54	33.3%	0.001
<60 Gy	10	10%