Review Article
Smoldering Multiple Myeloma
Table 3
Risk factors predicting high-risk SMM.
| | Risk factors | Patients with risk factors accounting for the population of SMM | Probability of 2-year progression to symptomatic MM |
| | Bone marrow plasma cells ≥ 60% | 2–10% | 90% | | Serum-free light-chain ratio ≥ 100 | 15% | 80% | | Abnormal magnetic resonance imaging (>1 focal lesion) | 15% | 70% | | High peripheral blood plasma cellsa | 15% | 70% |
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Defined as absolute peripheral blood plasma cells > 5000 106/L and/or >5% cytoplasmic immunoglobulin (Ig) positive plasma cells per 100 peripheral blood mononuclear cells.
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