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BioMed Research International
Volume 2015, Article ID 626948, 9 pages
http://dx.doi.org/10.1155/2015/626948
Research Article

Heterogeneity of Breast Cancer Associations with Common Genetic Variants in FGFR2 according to the Intrinsic Subtypes in Southern Han Chinese Women

1School of Biotechnology, Southern Medical University, Shatai Southern Road 1023, Baiyun District, Guangzhou, Guangdong 510515, China
2Institute of Pediatrics, Guangzhou Women and Children Medical Center, Jinsui Road 9, Tianhe District, Guangzhou, Guangdong 510623, China
3Breast Center Nanfang Hospital, Southern Medical University, Shatai Southern Road 1023, Baiyun District, Guangzhou, Guangdong 510515, China
4Department of Primary Public Health, Guangzhou Center for Disease Control and Prevention, Qide Road 1, Baiyun District, Guangzhou, Guangdong 510440, China
5Obstetrics Outpatient Clinic, Guangzhou Women and Children Medical Center, Jinsui Road 9, Tianhe District, Guangzhou, Guangdong 510623, China

Received 9 May 2015; Revised 3 August 2015; Accepted 18 August 2015

Academic Editor: Zhaoming Wang

Copyright © 2015 Huiying Liang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. F. Easton, K. A. Pooley, A. M. Dunning et al., “Genome-wide association study identifies novel breast cancer susceptibility loci,” Nature, vol. 447, no. 7148, pp. 1087–1093, 2007. View at Google Scholar
  2. B. Gold, T. Kirchhoff, S. Stefanov et al., “Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 11, pp. 4340–4345, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. D. J. Hunter, P. Kraft, K. B. Jacobs et al., “A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer,” Nature Genetics, vol. 39, no. 7, pp. 870–874, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. N. Stacey, A. Manolescu, P. Sulem et al., “Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer,” Nature Genetics, vol. 39, no. 7, pp. 865–869, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. N. Stacey, A. Manolescu, P. Sulem et al., “Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer,” Nature Genetics, vol. 40, no. 6, pp. 703–706, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Zheng, J. Long, Y.-T. Gao et al., “Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1,” Nature Genetics, vol. 41, no. 3, pp. 324–328, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Shan, W. Mahfoudh, S. P. Dsouza et al., “Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians,” Breast Cancer Research and Treatment, vol. 135, no. 3, pp. 715–724, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Garcia-Closas, F. J. Couch, S. Lindstrom et al., “Genome-wide association studies identify four ER negative-specific breast cancer risk loci,” Nature Genetics, vol. 45, no. 4, pp. 392–398, 2013. View at Google Scholar
  9. W. Han, J. H. Woo, J.-H. Yu et al., “Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype,” Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 5, pp. 793–798, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. S. Udler, K. B. Meyer, K. A. Pooley et al., “FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation,” Human Molecular Genetics, vol. 18, no. 9, pp. 1692–1703, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Sørlie, C. M. Perou, R. Tibshirani et al., “Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 19, pp. 10869–10874, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. C. M. Perou, T. Sørile, M. B. Eisen et al., “Molecular portraits of human breast tumours,” Nature, vol. 406, no. 6797, pp. 747–752, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Chan, S. M. Ji, C. S. Liaw et al., “Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population,” Breast Cancer Research and Treatment, vol. 136, no. 1, pp. 209–220, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Campa, M. Barrdahl, K. K. Tsilidis et al., “A genome-wide ‘pleiotropy scan’ does not identify new susceptibility loci for estrogen receptor negative breast cancer,” PLoS ONE, vol. 9, no. 2, Article ID e85955, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. J. R. Palmer, E. A. Ruiz-Narvaez, C. N. Rotimi et al., “Genetic susceptibility loci for subtypes of breast cancer in an African American population,” Cancer Epidemiology Biomarkers and Prevention, vol. 22, no. 1, pp. 127–134, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Garcia-Closas, P. Hall, H. Nevanlinna et al., “Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics,” PLoS Genetics, vol. 4, no. 4, Article ID e1000054, 2008. View at Google Scholar
  17. M. Garcia-Closas and S. Chanock, “Genetic susceptibility loci for breast cancer by estrogen receptor status,” Clinical Cancer Research, vol. 14, no. 24, pp. 8000–8009, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. X. He, G. Yao, F. Li, M. Li, and X. Yang, “Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern China,” International Journal of Molecular Sciences, vol. 15, no. 2, pp. 2130–2141, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Sun, X. Yang, C. Ye et al., “Risk-association of CYP11A1 polymorphisms and breast cancer among han Chinese women in Southern China,” International Journal of Molecular Sciences, vol. 13, no. 4, pp. 4896–4905, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. Q. Pan, Y. Ning, L. Z. Chen et al., “Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population.,” Genetics and Molecular Research, vol. 11, no. 4, pp. 4299–4306, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Tong, X.-X. Yang, M.-F. Liu et al., “Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 11, pp. 5599–5603, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. Ramon, J. Escribal, I. Casas et al., “Age at first full-term pregnancy, lactation and parity and risk of breast cancer: a case-control study in Spain,” European Journal of Epidemiology, vol. 12, no. 5, pp. 449–453, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Ma, J. Luo, M. F. Press, Y. Wang, L. Bernstein, and G. Ursin, “Is there a difference in the association between percent mammographic density and subtypes of breast cancer? Luminal A and triple-negative breast cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 2, pp. 479–485, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. L. S. Dominici, E. A. Mittendorf, X. Wang et al., “Implications of constructed biologic subtype and its relationship to locoregional recurrence following mastectomy,” Breast Cancer Research, vol. 14, no. 3, article R82, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Keam, S.-A. Im, K.-H. Lee et al., “Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis,” Breast Cancer Research, vol. 13, article R22, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. X. Solé, E. Guinó, J. Valls, R. Iniesta, and V. Moreno, “SNPStats: a web tool for the analysis of association studies,” Bioinformatics, vol. 22, no. 15, pp. 1928–1929, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Wesche, K. Haglund, and E. M. Haugsten, “Fibroblast growth factors and their receptors in cancer,” Biochemical Journal, vol. 437, no. 2, pp. 199–213, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. K. B. Meyer, A.-T. Maia, M. O'Reilly et al., “Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer,” PLoS Biology, vol. 6, no. 5, article e108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Liang, P. Chen, Z. Hu et al., “Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women,” Carcinogenesis, vol. 29, no. 12, pp. 2341–2346, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Zheng, W. Wen, Y.-T. Gao et al., “Genetic and clinical predictors for breast cancer risk assessment and stratification among chinese women,” Journal of the National Cancer Institute, vol. 102, no. 13, pp. 972–981, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Long, X.-O. Shu, Q. Cai et al., “Evaluation of breast cancer susceptibility loci in Chinese women,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 9, pp. 2357–2365, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. F. Chen, M. Lv, Y. Xue et al., “Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality,” Immunogenetics, vol. 64, no. 1, pp. 71–76, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Raskin, M. Pinchev, C. Arad et al., “FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 5, pp. 1060–1065, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Fu, C. Wang, M. Huang, C. Song, S. Lin, and H. Huang, “Polymorphisms in second intron of the FGFR2 gene are associated with the risk of early-onset breast cancer in Chinese Han women,” Tohoku Journal of Experimental Medicine, vol. 226, no. 3, pp. 221–229, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Sapkota, Y. Yasui, R. Lai et al., “Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm,” PLoS ONE, vol. 8, no. 5, Article ID e62550, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Broeks, M. K. Schmidt, M. E. Sherman et al., “Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium,” Human Molecular Genetics, vol. 20, no. 16, pp. 3289–3303, 2011. View at Google Scholar
  37. Y. A. Luqmani, M. Graham, and R. C. Coombes, “Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues,” British Journal of Cancer, vol. 66, no. 2, pp. 273–280, 1992. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Siddiqui, S. Chattopadhyay, M. S. Akhtar et al., “A study on genetic variants of Fibroblast growth factor receptor 2 (FGFR2) and the risk of Breast cancer from North India,” PLoS ONE, vol. 9, no. 10, Article ID e110426, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. S. H. Nordgard, F. E. Johansen, G. I. G. Alnæs, B. Naume, A.-L. Børresen-Dale, and V. N. Kristensen, “Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes,” Breast Cancer Research, vol. 9, no. 6, article 113, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. G. A. Colditz, B. A. Rosner, W. Y. Chen, M. D. Holmes, and S. E. Hankinson, “Risk factors for breast cancer according to estrogen and progesterone receptor status,” Journal of the National Cancer Institute, vol. 96, no. 3, pp. 218–228, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Ma, L. Bernstein, M. C. Pike, and G. Ursin, “Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies,” Breast Cancer Research, vol. 8, no. 4, article R43, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. J. J. de Ronde, J. Hannemann, H. Halfwerk et al., “Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response,” Breast Cancer Research and Treatment, vol. 119, no. 1, pp. 119–126, 2010. View at Publisher · View at Google Scholar · View at Scopus