Research Article

Single-Fraction Radiotherapy for CD30+ Lymphoproliferative Disorders

Table 1

Characteristics of CD30+ lymphoproliferative disorder (LPD) patients treated with radiation therapy (RT).

PatientSex/age (y) at presentationAntecedent or synchronous lymphomaTNM stage at presentationNumber of lesions treated with RTLocation of lesionDate of completion of RTClinical or pathologic diagnosisHistological typeImmunophenotypePrior therapiesTotal dose (Gy)/dose per fraction/energy/
bolus/IDL
Response at RT siteLR/follow-up (m)

1M/48n/aT3b1Right lower extremity08/15/11Path.n/sCD4+/CD30+Oral/IL methotrexate, topical imiquimod8/8, 12 MeV e, 1 cm bolus, 90% IDLCRN/16

2 M/60Synchronous subcutaneous NHL T3b 6Left groin12/26/02Clin.CHOP × 6c45/2.5, 10 MeV e, 1 cm bolus, 90% IDLCRN/131
Right femoral region12/26/02Clin.45/2.5, 10 MeV e, 1 cm bolus, 90% IDLCRN/131
Right axilla12/26/02Path.CCD4+/CD30+45/2.5, 10 MeV e, 1 cm bolus, 90% IDLCRN/131
Left axilla12/26/02Clin.45/2.5, 10 MeV e, 1 cm bolus, 90% IDLCRN/131
Right neck4/7/03Path.n/sCD4+/CD30+45/2.5, 10 MeV e, 1 cm bolus, 90% IDLCRN/127
Right elbow3/01/06Clin.45/2.5, 10 MeV e, 1 cm bolus, 90% IDLCRN/99

3 F/83Antecedent HL T3b 2Left lateral thigh11/12/10Path.n/sCD4+/CD30+IL methotrexate, IL triamcinolone acetonide8/8, 10 MeV e, 1 cm bolus, 95% IDLCRN/37
Left calf09/07/11Path.CCD4+/CD30+IL steroids8/8, 12 MeV e, 1 cm bolus, 90% IDLCRN/27

4F/53n/aT3a1Upper lip10/21/99Path.An/s42/2, 10 MeV e, 0.5 cm bolus, 90% IDLCRN/146

5F/34n/aT3b1Left forearm7/23/12Path.CCD4+/CD30+Topical methotrexate, PUVA, triamcinolone acetonide7.5/7.5, 12 MeV e, 1 cm bolus, 90% IDLCRN/18

6M/15n/aT3b1Left back9/28/08Clin.RT, prednisone, minocycline40/2, 12 MeV e, 1 cm bolus, 95% IDLCRN/66

Staging per Kim et al., 2007 [25].
HL = Hodgkin’s Lymphoma, NHL = Non-Hodgkin’s Lymphoma, n/s = not specified, IL = intralesional, e = electron, IDL = isodose line, CR = complete response, AWD = alive with disease, LR = local recurrence, and N = none.