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BioMed Research International
Volume 2015, Article ID 630179, 13 pages
http://dx.doi.org/10.1155/2015/630179
Research Article

A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines

1Cellular and Molecular Physiology Group, Biomedical Research Institute, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 111321, Colombia
2Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Bogotá 111321, Colombia
3Department of Chemistry, Faculty of Sciences, Universidad Nacional de Colombia, Bogotá 111321, Colombia
4Centro de Medicina Regenerativa, Faculty of Medicine, Clínica Alemana, Universidad del Desarrollo, 7690000 Santiago, Chile

Received 1 June 2015; Revised 16 September 2015; Accepted 28 September 2015

Academic Editor: Paul M. Tulkens

Copyright © 2015 Víctor A. Solarte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material shows photomicrographs of the OSCC cell lines at different culture confluence; expression of epithelial and mesenchymal markers in both SCC15 cell subpopulations; inhibition of apoptosis by the caspases inhibitor Z-VAD-FMK; evaluation of the hemolytic effect of LfcinB25 derived peptides, and the effect of a second addition of the tetrameric peptide on OSCC cell viability.

  1. Supplementary Materials