Research Article
A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines
Table 2
IC50 of LfcinB-derived peptides.
| | Cell line | Peptide | IC50 (µM) | | 1 hour | 3 hours | 24 hours |
| | CAL27 | LfcinB25 |
5.248 ± 1.54 | 9.694 ± 1.38 | 8.67 ± 1.44 | | LfcinB(20–25) | >101.4 | >101.4 | >101.4 | | LfcinB-Pal | 22.77 ± 1.12 | 22.6 ± 1.02 | 21.54 ± 1.05 | |
LfcinB(20–25)4 | 16.01 ± 1.36 | 17.44 ± 1.77 | 9.016 ± 1.38 |
| | SCC15 | LfcinB25 | >32 | >32 | 4.04 ± 2.87 | | LfcinB(20–25) | >101.4 | >101.4 | >101.4 | | LfcinB-Pal | >67.26 | >67.26 | >67.26 | | LfcinB(20–25)4 | 13.58 ± 1.06 | 12.58 ± 1.06 | 9.048 ± 1.07 |
| | Het-1A | LfcinB25 | >32 | 4.127 ± 1.20 | 8.12 ± 1.20 | | LfcinB(20–25) | >101.4 | >101.4 | >101.4 | | LfcinB-Pal | >67.26 | 62.19 ± 1.56 | >67.26 | | LfcinB(20–25)4 | >24.96 | 18.79 ± 1.11 | 17.37 ± 1.11 |
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