Effect of Atlas Vertebrae Realignment in Subjects with Migraine: An Observational Pilot Study

Table 4

Descriptive statistics (mean and standard deviation) for headache diary and migraine specific health related quality of life measures (). Values reported at baseline, week-four, and week-eight for headache diary, HIT-6², and MSQL^4,5,6; baseline and week-twelve (week eight after intervention) for the MIDAS⁷. Baseline and follow-up differences analyzed using the paired -test, described as mean difference and 95% CI¹. A score decrease indicates improvement for diary and HIT-6² results. MSQL^4,5,6 scores increase with subject HRQoL³ improvement.

(a)

	Baseline; mean; (SD)	Week-4; mean; (SD)	Week-8; mean; (SD)	Difference baseline to week-4; mean (95% CI^1); value	Difference baseline to week-8; mean (95% CI^1); value
Headache diary
Headache days per month	14.5; (5.7)	11.4; (5.2)	8.7; (4.3)	3.1 (0.19, 6.0)	5.7 (2.0, 9.4)
Headache intensity	2.8; (0.96)	2.6; (0.89)	2.1; (1.18)	0.17 (−0.53, 0.86)	0.69 (−0.32, 1.71)
Health Related Quality of Life (HRQoL)
HIT-6^2	64.2; (3.8)	55.3; (7.7)	53.8; (6.8)	8.9 (4.9, 13.0)	10.4 (6.9, 13.8)
MSQL-R^6	38.4; (17.4)	69.1; (22.7)	73.5; (28.0)	30.7 (22.4, 38.9)	35.1 (23.5, 46.6)
MSQL-E^4	53.3; (23.5)	82.4; (16.9)	81.2; (29.2)	29.1 (15.9, 42.3)	27.9(12.9, 43.1)
MSQL-P^5	54.1; (18.1)	83.2; (16.9)	86.8; (16.9)	29.1 (16.8, 41.4)	32.7 (21.3, 44.5)

(b)

	Baseline; mean; (SD)	Week-12; mean; (SD)	Difference; mean (95% CI); value
MIDAS^7	46.7; (27.7)	14.6; (23.8)	32.1 (13.2, 51.0)

CI: confidence interval.
²HIT-6: Headache Impact Test-6.
³HRQoL: Health Related Quality of Life.
⁴MSQL-E: Migraine-Specific Quality of Life Measure-Emotional.
⁵MSQL-P: Migraine-Specific Quality of Life Measure-Physical.
⁶MSQL-R: Migraine-Specific Quality of Life Measure-Restrictive.
⁷MIDAS: Migraine Disability Assessment Scale.