BioMed Research International / 2015 / Article / Tab 3 / Review Article
The Ovariectomized Rat as a Model for Studying Alveolar Bone Loss in Postmenopausal Women Table 3 Summary of studies investigating estrogen replacement therapy and mandibular health in ovariectomized rats.
Rat strain Sample size per group Age at OVX (wks) OVX duration (wks) Estrogen dose; duration (wks) Main findings for mandible, compared to OVX Reference Wistar Unknown 2
17 -estradiol 1.5 g/day continuous infusion; 2 (i) Less nuclei (osteoclasts) [54 ] Sprague-Dawley 13 7 17 -estradiol 10 g/kg 5 days/wk; 7 (i) 36% less periodontal ligament space [55 ] Wistar 11 11 17 -estradiol 20 g/kg daily; 11 (i) 41% greater bone density [56 ] Wistar 26 16 Estriol 100 g/kg 5 days/wk; 12 (i) Improved trabecular BMD and BMC [57 ] Sprague-Dawley 13 62 17 -estradiol 10 g/kg 4 days/wk; 10 (i) 38% less periosteal mineralizing surface (ii) 88% less endosteal double-labeled surface (iii) 51% less endosteal mineralizing surface (iv) 71% less endosteal mineral apposition rate [58 ]
OVX, ovariectomized; BMD, bone mineral density; BMC, bone mineral content.