|
| Pandharipande et al. (2007) [13] | Shehabi et al. (2009) [14] | Maldonado et al. (2009) [15] |
|
ICU type | Medical/surgical | Cardiothoracic | Cardiothoracic |
Subjects | | | |
Number | 103 | 299 | 90 |
Age (median, IQR) | Dexmedetomidine: 60 (49–65) Lorazepam: 59 (45–67) | Dexmedetomidine: 71.5 (66–76) Morphine: 71 (65–75) | Dexmedetomidine: 55 (16) Propofol: 58 (18) Midazolam: 60 (16) |
Male gender (%) | 51.5 | 75.3 | 63.6 |
Intervention (median, IQR) | Dexmedetomidine: 0.74 mcg/kg/h (0.39–1.04) Lorazepam: 3 mg/h (2.2–6) | Dexmedetomidine: 0.48 mcg/kg/h (0.23–0.76) Morphine: 49 mcg/kg/h (20–81) | Dexmedetomidine: 0.35 mcg/kg/h Propofol: 26.3 mcg/kg/h Midazolam: 1.5 mg/h |
Primary outcome | Composite of delirium-free and coma-free days | Delirium incidence within 5 days of surgery | Incidence of post-operative delirium |
Randomization | Computer generated, permuted blocks | Computer-generated blocks of 10 | Random drawing the evening before surgery, blocked |
Concealment | Known only to study pharmacist | Known only to study pharmacist | Open-label |
Blinding | Solutions identical in color (clear) | Solutions identical in color (clear) | Unblinded |
Jadad Score | 4 | 3 | 2 |
|