Functions of Kinesin Superfamily Proteins in Neuroreceptor Trafficking

Table 1

Neuroreceptors transported by kinesin superfamily proteins (KIFs).

Motor proteins	Superfamily	Neuroreceptors	Interactome	Transport	References
KIF5	Kinesin-1	AMPARs (GluA2)	GRIP1	Dendritic	[19, 52]
unc116/KIF5	Kinesin-1	GLR-1	Unknown	Unknown	[58]
KLP-4/KIF13	Kinesin-3	GLR-1	Unknown	Unknown	[61]
KIF1A	Kinesin-3	AMPARs (GluA2/3)	liprin-α	Axonal and Dendritic	[59, 60]^#
KIF17	Kinesin-2	KARs (GluR5)	Undefined	Dendritic	[31]
KIF17	Kinesin-2	NMDARs (GluN2B)	m-Lin10 (Mint1, X11); m-Lin2 (CASK); m-Lin7 (MALS, Velis); SAP97	Dendritic	[69, 72, 77, 93]
KIF11/Eg5	Kinesin-5	NMDARs (GluN1)	Undefined	Undefined	[84]
KIF5	Kinesin-1	GABAARs	HAP1	Dendritic	[88]
KIF5A	Kinesin-1	GABAARs	GABARAP	Dendritic	[89]
KIF21B	Kinesin-4	GABAARs	GABARAP	Dendritic	[94]
KIF5C	Kinesin-1	GABABR1a	Undefined	Axonal	[91]

Indication: the regulatory role of KIF protein on neuroreceptors trafficking was found in C. elegans, while others were studied in mammalian cells.  ^#The regulatory role of KIF1A on AMPAR trafficking was deduced from previous studies. There is no direct evidence on whether KIF1A could regulate AMPARs transport in axons and dendrites up till now.