BioMed Research International / 2015 / Article / Tab 2

Review Article

Zebrafish as a Model for the Study of Human Myeloid Malignancies

Table 2

The advantages and weaknesses in the xenograft model of zebrafish and mouse.

ItemZebrafishMouse

StrengthsMaintenance costLowAvailable
Maintenance spaceSmallLarge
OffspringLarge numberLess number
Immune systemLack in early zebrafish embryosInnate and adaption
ObservationVisualization (transparency and transgenic lines)Limitation
Readout timeHours to daysDays to months
Cell numbers required for xenotransplantation per animalLessLarge
High-throughput drug screeningAvailableLimitation

WeaknessesSize of organs/vesselsSmallLarge
Body temperatureLowHigh
Lack of organsBreast, lung, etc.
Zebrafish antibodiesLimitationMore
Adult immune-permissive linesUnavailableAvailable

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