Zebrafish as a Model for the Study of Human Myeloid Malignancies

Table 2

The advantages and weaknesses in the xenograft model of zebrafish and mouse.

	Item	Zebrafish	Mouse
Strengths	Maintenance cost	Low	Available
	Maintenance space	Small	Large
	Offspring	Large number	Less number
	Immune system	Lack in early zebrafish embryos	Innate and adaption
	Observation	Visualization (transparency and transgenic lines)	Limitation
	Readout time	Hours to days	Days to months
	Cell numbers required for xenotransplantation per animal	Less	Large
	High-throughput drug screening	Available	Limitation
Weaknesses	Size of organs/vessels	Small	Large
	Body temperature	Low	High
	Lack of organs	Breast, lung, etc.
	Zebrafish antibodies	Limitation	More
	Adult immune-permissive lines	Unavailable	Available