|
| Surgical procedure | Analgesic modality | Outcomes | Study design | Sample size | Journals (year) | 1st author | Citation |
|
| Nerve block |
| Mastectomy plus immediate reconstruction | PVB with Bupivacaine 0.5% versus nonblock | Reduced length of stay and PONV in PVB group | Retrospective study | | Ann. Surg. Oncol. (2013) | Coopey | [12] |
| Mastectomy with or without immediate reconstruction | PVB versus nonblock | PVB reduced PONV incidence | Retrospective study | | Ann. Surg. Oncol. (2014) | Fahy | [13] |
| Pt mastectomy with SLNB, mastectomy with or without SLNB or ALND, and mastectomy with reconstruction | PVB with ropivacaine 0.5% versus sham block | Higher QoR score, reduced discharge time, and reduced PONV in PVB group | Prospective study | | Anesthesiology (2014) | Abdallah | [14] |
| Mastectomy with ALND | PECS versus nonblock | PECS reduced PONV incidence | Prospective study | | Reg. Anesth. Pain Med. (2015) | Bashandy | [15] |
|
| LA injection at surgical site |
| Pt mastectomy with or without ALND | Ropivacaine 0.375% versus saline before surgery | Incidence of PONV did not change between two groups | Prospective study | | Acta Anaesthesiol. Scand. (2000) | Johansson | [16] |
| Mastectomy with ALND | Bupivacaine 0.25% versus noninjection | Reduced hospital stay, pain intensity in bupivacaine group | Retrospective study | | Acta Chir. Belg. (2011) | Lu | [17] |
|
| Systemic analgesic drug |
| Mastectomy with or without ALND, Pt mastectomy with or without ALND | Clonidine or placebo | Clonidine reduced PONV incidence | Prospective study | | Anesthesiology (2002) | Oddby-Muhrbeck | [20] |
| Mastectomy with ALND | Dexmedetomidine or saline | Higher QoR score in dexmedetomidine group | Prospective study | | Minerva Anestesiol. (2013) | Kim | [21] |
| Mastectomy with ALND | Gabapentin or placebo before surgery | Gabapentin reduced pain intensity but not PONV incidence | Prospective study | | Anesthesiology (2002) | Dirks | [18] |
| Mastectomy with or without ALND, Pt mastectomy with or without ALND | Pregabalin or placebo before surgery | Pregabalin reduced pain intensity but not PONV incidence | Prospective study | | Acta Anaesthesiol. Scand. (2011) | Kim | [19] |
| Pt mastectomy with or without ALND | Magnesium or saline | Higher QoR score in magnesium group | Prospective study | | Magnes. Res. (2013) |
de Oliveira | [22] |
| Mastectomy with ALND | Dexamethasone or placebo | Incidence of PONV and intensity of pain reduced in dexamethasone group | Prospective study | | BMC Cancer (2010) | Gómez-Hernández | [26] |
| Pt mastectomy with or without ALND | Betamethasone or no-treatment control | Incidence of PONV and intensity of pain reduced in betamethasone group | Prospective study | | J. Clin. Anesth. (2014) | Olanders | [25] |
|
