Potential Therapeutic Benefit of Combining Gefitinib and Tamoxifen for Treating Advanced Lung Adenocarcinoma

Figure 3

Combination treatment of Gef and TAM resulted in a reduction in LAC cell growth. (a, b) Both Gef and TAM suppressed EGFR mutant PC9 colony forming numbers, while combination treatment further suppressed them. (c, d) Gef and TAM each had a marginal suppression effect on EGFR wild type A549 cell colony forming numbers; however, combination treatment led to significant suppression of colony forming capacity. (a) and (c) are representative sets of images from 3 reproducible independent experiments, where (b) and (d) are the quantitation of results. Indicating value < 0.05, indicating value less than 0.01, and indicating value less than 0.001.

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