Research Article
Wide Local Excision for Dermatofibrosarcoma Protuberans: A Single-Center Series of 90 Patients
Table 3
Review of the literature regarding the clinical characteristics and surgical outcome in the treatment of DFSP.
| | Authors | Publishing year | Study design | Number of patients (male/female) | Age (years) | Resection
margin (cm) | Adjuvant treatment | Overall recurrence rate (%) | Recurrence period
(months) | Follow-up period (years) |
| | Smola et al. [15] | 1991 | Retrospective | 20 | NR | 1.0–5.0 | NR | 30.0 | NR | 8.8 | | Rutgers et al. [16] | 1992 | Retrospective | 11 | NR | >2.0 | NR | 0.0 | NR | 13.2 (2–28) | | Stojadinovic et al. [17] | 2001 | Retrospective | 14 (6/8) | 37 (26–73) | ≥2.0 (12),
<2.0 (2) | NR | 7.0 | NR | 8.4 (1.0–15.6) | | Chang et al. [18] | 2004 | Retrospective | 60 (23/37) | 36 (10–70) | 3.1 (1.0–6.0) | RT (3) | 16.7 | 38.0 (1–100) | 4.9 | | Monnier et al. [4] | 2006 | Retrospective | 66 (36/30) | 32.8 (0–67) | <0.9–5.0 | NR | 27.0 | 31.8 | 9.6 | | Popov et al. [19] | 2007 | Prospective | 40 (22/18) | 45 | 3.1 | NR | 0.0 | NR | 3.3 | | Paradisi et al. [10] | 2008 | Retrospective | 38 (16/22) | 44 (10–83) | 2.0–5.0 | NR | 13.0 | NR | 4.8 (2–10) | | Heuvel et al.[20] | 2010 | Retrospective | 38 (19/11) | 38 (8–77) | 2.0–3.0 | RT (8) | 10.5 | NR (81, 11) | 7.4 (1.0–21.8) | | Farma et al. [21] | 2010 | Retrospective | 204 (76/128) | 41 (1–84) | 2.0 (0.5–3.0) | RT (9) | 1.0 | 48.5 (13–84) | 5.3 (0.1–17.5) | | Cai et al. [22] | 2012 | Retrospective | 223 | 38 (11–80) | >1.5 | RT (34) | 8.5 | 18.5 (3–129) | 7.0 (0.6–23.8) | | Hamid et al. [23] | 2013 | Retrospective | 45 (30/15) | 38.4 (7–65) | 2.0–3.0 | NR | 22.2 | 32.0 | 5.7 (0.5–13) | | Goldberg et al. [11] |
2015 | Retrospective | 25 (8/17) | 46.1 (12–84) | 2.8 | RT (1) | 0.0 | NR | 9.0 | | Our study | | Retrospective | 90 (53/37) | 34.6 (0–78) | 3.0 (1.0–5.0) | RT (6)
RT + C (2) | 5.5 | 10.0 (5–14) | 3.6 (0.1–23.5) |
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DFSP: dermatofibrosarcoma protuberans, RT: radiation, and NR: not recorded.
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