Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort

Table 2

Results of sample (: eight SNP-SNP interactions associated with cingulate amyloid burden. The Bonferroni corrected values (<0.05) and of the SNP-SNP interaction term are shown in bold.

Number	SNP1 SNP2	Gene	CHR	Main effect	Interaction		R square
				value	value	Corrected value	Age + Sex + Dx^a			SNP1 + SNP2^d	SNP1 SNP2^e
1	rs2194938 rs7644138	CLSTN2	3			0.026	0.110	0.161	0.018	0.034	0.049
		FHIT	3
2	rs7916162 rs2326536	TACC2	10			0.038	0.110	0.161	0.018	0.020	0.049
		PRNP	20
3	rs2295873 rs7794838	TACC2	10			0.035	0.110	0.161	0.018	0.037	0.041
		IGFBP3	7
4	rs2295874 rs2326536	TACC2	10			0.042	0.110	0.161	0.018	0.024	0.039
		PRNP	20
5	rs13056151 rs17594541	BCR	22			0.048	0.110	0.161	0.018	0.035	0.026
		MAGI2	7
6	rs13426621 rs7037332	LOC388942	2			0.017	0.110	0.161	0.018	0.042	0.023
		TYRP1	9
7	rs16936424 rs10504164	LOC387761	11			0.045	0.110	0.161	0.018	0.037	0.017
		NA	8
8	rs16939265 rs6854047	HNF4G	8			0.034	0.110	0.161	0.018	0.027	0.013
		RWDD4	4	0.000464343

Age + Sex + Dx: percent of variance in cingulate amyloid burden explained by age, gender, and diagnosis.
^bAPOE: percent of additional variance in cingulate amyloid burden explained by the APOE genotype after accounting for age, gender, and diagnosis.
^cBCHE: percent of additional variance in cingulate amyloid burden explained by the BCHE SNP after accounting for age, gender, diagnosis, and APOE genotype.
^dSNP1 + SNP2: percent of additional variance in cingulate amyloid burden explained by the combined main effect of SNP1 and SNP2 after accounting for age, gender, diagnosis, APOE genotype, and the BCHE SNP.
^eSNP1 SNP2: percent of additional variance in cingulate amyloid burden explained by the interaction effect of SNP1 and SNP2 after accounting for age, gender, diagnosis, APOE genotype, the BCHE SNP, SNP1, and SNP2.
Nearest gene proximal to the SNP.