Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort

Table 3

Results of sample (): eight SNP-SNP interaction associations with three CSF biomarkers.

Number	SNP1 SNP2	A ( square)					t-Tau/A ( square)					p-Tau/A ( square)
		Age + Sex + Dx	APOE	BCHE	SNP1 + SNP2	SNP1 SNP2	Age + Sex + Dx	APOE	BCHE	SNP1 + SNP2	SNP1 SNP2	Age + Sex + Dx	APOE	BCHE	SNP1 + SNP2	SNP1 SNP2
1	rs2194938 rs7644138	0.108	0.187	0.012	0.021	0.008	0.132	0.153	0.022	0.016	0.014	0.134	0.129	0.024	0.007	0.011
2	rs7916162 rs2326536	0.108	0.187	0.012	0.003	0.019	0.132	0.153	0.022	0.004	0.011	0.134	0.129	0.024	0.005	0.014
3	rs2295873 rs7794838	0.108	0.187	0.012	0.014	0.012	0.132	0.153	0.022	0.017	0.011	0.134	0.129	0.024	0.016	0.007
4	rs2295874 rs2326536	0.108	0.187	0.012	0.003	0.018	0.132	0.153	0.022	0.002	0.012	0.134	0.129	0.024	0.003	0.015
5	rs13056151 rs17594541	0.108	0.187	0.012	0.005	0.005	0.132	0.153	0.022	0.005	0.006	0.134	0.129	0.024	0.005	0.004
6	rs13426621 rs7037332	0.108	0.187	0.012	0.002	0.002	0.132	0.153	0.022	0.006	0.012	0.134	0.129	0.024	0.004	0.006
7	rs16936424 × rs10504164	0.108	0.187	0.012	0.018	0.004	0.132	0.153	0.022	0.014	0.008	0.134	0.129	0.024	0.009	0.003
8	rs16939265 × rs6854047	0.108	0.187	0.012	0.012	0.007	0.132	0.153	0.022	0.003	0.005	0.134	0.129	0.024	0.002	0.003