Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort

Table 4

Results of sample (: eight SNP-SNP interactions associated with cingulate amyloid burden.

Number	SNP1 SNP2	Gene	CHR	Main effect	Interaction		square
				value	value	corrected value	Age + Sex + Dx	APOE	BCHE	SNP1 + SNP2	SNP1 SNP2
1	rs2194938 rs7644138	CLSTN2	3			0.026	0.127	0.133	0.019	0.047	0.053
		FHIT	3
2	rs7916162 rs2326536	TACC2	10			0.038	0.127	0.133	0.019	0.027	0.055
		PRNP	20
3	rs2295873 rs7794838	TACC2	10			0.035	0.127	0.133	0.019	0.059	0.059
		IGFBP3	7
4	rs2295874 rs2326536	TACC2	10			0.042	0.127	0.133	0.019	0.031	0.046
		PRNP	20
5	rs13056151 rs17594541	BCR	22			0.048	0.127	0.133	0.019	0.034	0.037
		MAGI2	7
6	rs13426621 rs7037332	LOC388942	2			0.017	0.127	0.133	0.019	0.049	0.039
		TYRP1	9
7	rs16936424 rs10504164	LOC387761	11			0.045	0.127	0.133	0.019	0.051	0.023
		NA	8
8	rs16939265 rs6854047	HNF4G	8			0.034	0.127	0.133	0.019	0.040	0.026
		RWDD4	4

Nearest gene proximal to the SNP.