Research Article
Investigating the Pretreatment miRNA Expression Patterns of Advanced Hepatocellular Carcinoma Patients in Association with Response to TACE Treatment
Table 3
The literature suggested functions of the 12 miRNAs in HCC.
| miRNA | Function |
| miR-10a | Is involved in metastatic process of HCC. |
| miR-23a/24/27a | This cluster can promote hepatic metastasis. |
| miR-26a | Acts as a tumor suppressor in liver; patients with lower miR-26 level have shorter overall survival. |
| miR-30c/30e | miR-30 family expression is significantly expressed in HCC patients with metastasis. |
| miR-31 | Is significantly expressed in HCC patients and its expression is correlated with liver cirrhosis. |
| miR-106b | Plays a critical role in development of HCC metastasis. |
| miR-133b | Plays a role in the development of HCC by regulating CD133(+) liver tumor initiating cells. |
| miR-199a-3p | Is associated with progression of liver fibrosis and can influence the doxorubicin sensitivity of human hepatocarcinoma cells. |
| miR-200b | Can mediate hepatocellular carcinoma cell migration, closely associated with progression of liver fibrosis. |
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