Multiple Sclerosis Increases Fracture Risk: A Meta-Analysis

Table 1

Characteristics of the included studies.

First author	Year	Study design	Mean age	Women (%)	Follow-up years	Sample size	Adjusted for
Bazelier [6]	2011	Cohort	44.8	70	11	38925	Age, sex, the use of oral/intravenous glucocorticoids, antidepressants, hypnotics/anxiolytics, anticonvulsants, and opioids in the previous 6 months, history of falling at index date, history of fracture at index date, history of cerebrovascular disease, epilepsy, history of smoking, BMI
Moen [7]	2011	Cohort	37.1	72	NA	231	NA
Bazelier [8]	2012	Cohort	43.6	72	11	15056	Age, sex, the use of antidepressants, anticonvulsants, and bisphosphonates in the previous 6 months
Bazelier [9]	2012	Cohort	46.4	66	12	68430	NA
Bazelier [10]	2012	Cohort	36.9	67	7.2	18399	Age, sex, the use of oral/intravenous glucocorticoids, antidepressants, hypnotics/anxiolytics, anticonvulsants, and opioids in the previous 6 months, history of cerebrovascular disease, epilepsy
Dennison [11]	2012	Cohort	NA	100	3	52960	Heart disease, osteoarthritis, chronic obstructive pulmonary disease, Parkinson's disease
Ramagopalan [12]	2012	Cohort	NA	69	11	7908570	NA
Bhattacharya [13]	2014	Cohort	65	79	20	1066404	Sex, race
Gregson [14]	2014	Cohort	≥55	100	3	60393	Age

NA, not available.