Review Article
Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
Table 1
Laboratorial methods used for posttherapeutic cure criteria in human Chagas disease and Trypanosoma cruzi infection in experimental models.
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Conventional serological tests: CFR (complement fixation reaction); IHA (indirect hemagglutination assay); IIF (indirect Immunofluorescence test), and ELISA (enzyme-linked immunosorbent assay); nonconventional serological tests: ML (complement mediated lysis); FC-ALTA (flow cytometry anti-live trypomastigotes antibodies); FC-AFEA (flow cytometry anti-fixed epimastigotes antibodies); FC-ATE (flow cytometry anti-live amastigote/trypomastigotes and fixed epimastigote antibodies); direct parasitological tests: fresh blood examination (FBE), trypomastigotes concentration (buffy coat, microhematocrit, and Strout tests); indirect parasitological tests: xenodiagnosis, hemoculture, and PCR. |