Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease

Figure 1

Fluorescence microscope images showing an example of lumbar SC section from a unilaterally lesioned animal, stained with anti-ChAT antibody plus 488 Alexa Fluor secondary antibody (green). Sections were counterstained with DAPI (blue) to visualize cell nuclei. The effect of neurotoxic lesion on the number of surviving motoneurons is evident in the right side of the cord, ipsilaterally to the injected muscle (IPSI), as compared to the contralateral side (CONTRA). Scale bar: 100 m. The arrows indicate the medial (M) to lateral (L) direction.