Computational Selection of RNA Aptamer against Angiopoietin-2 and Experimental Evaluation

Table 1

Sequences of RNA aptamers. Seq1~Seq15 are Ang2-specific aptamers, and Seq16 is an Ang1 specific aptamer.

Name	Sequence (5′-3′)	ZRANK score
Seq1	ACUAGCCUCAUCAGCUCAUGUGCCCCUCCGCCUGGAUCAC	−93.855
Seq2	UUAACCAUCAGCUCAUGGCCCCUGCCCUCUCAAGGACCAC	−82.722
Seq3	CACCAGACCGACAUCAGCUUAUGGCCCCUCACCCACACCG	−73.128
Seq4	CCACCGAUCGCAUCAGCUCAUGGCCCCUCCCGACCCGCCA	−72.227
Seq5	CCAGACGUUCUCGCCCCGCCGAUCAUCAGCGCUGGCCCUAU	−69.183
Seq6	CACUACCACGCCAUAUCAGCUAAUGGCCCCUCCCUACGCA	−73.305
Seq7	ACUCACCAGUCACCAUCAGCUCAUGCGCCCCUCCCCCGAC	−63.518
Seq8	UGACCAAGCCUCACGUUGAACCUGCCAGUAGACCCCGCCCA	−70.795
Seq9	GGAGCGCAAUUCGCCUCGCAAGUUGAACUCCGCUGGCGG	−74.153
Seq10	UAAGCUCUUUGGCUUAGCCCGACACGUUGAACUCCAGAGU	−65.73
Seq11	CACGGUACCACCAAGUCACACGUUGAACUCCAUGCAGCUG	−62.02
Seq12	CAUGUCUACAACAAUCUCGCCCGUUGAGUCUCGUCGAAUU	−68.159
Seq13	CACUCAGCGCCCUGCGAAACGUUGCCGCCUCCCAACGUCU	−74.432
Seq14	CUCUUUUUGUCCCCGCACGUUGAACUCCUGUCCCUCUACU	−73.895
Seq15	GAGGACGAUGCGGACUAGCCUCAUCAGCUCAUGUGCCCCUC	−80.325
Seq16	ACUCGAACAUUUCCACUAACCAACCAUACUAAAGCACCGC	−61.969