Systematic Analysis of the Associations between Adverse Drug Reactions and Pathways

Figure 6

The AA network and its properties. (a) The AA network. Each node is an ADR, and two ADRs were connected by a link when the pathways that were associated with these ADRs significantly overlapped. The significance of the overlapping was also evaluated by the values of the hypergeometric test (). (b) The heatmap of interaction frequency between any two SOCs. The highest percentage of interaction frequency of every SOC was labeled on the corresponding color column. (c) ADR clique 20. All ADRs in this clique were associated with three identical pathways. Every ADR node was colored according to the SOCs to which the ADR belonged.

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