Emerging Roles of MicroRNAs in EGFR-Targeted Therapies for Lung Cancer

Table 1

MicroRNAs that target EGFR signaling pathway involved in lung cancer.

MicroRNA(s)	Regulation	Potential function(s)	Reference(s)
let-7g	Down	Dramatically downregulated in EGFR/KRAS negative lung adenocarcinomas	[23]
miR-7	Down	Inhibits EGFR-PI3K-AKT signaling and reverses radio-resistance in various cancer cells	[20]
miR-27a	Down	Directly targets EGFR and contributes to mutant p53 gain-of-function	[36, 37]
miR-34a	Down	Regulates Axl receptor tyrosine kinase by targeting SIRT1 and MEK1	[38]
miR-128b	Down	Directly regulates EGFR expression in NSCLC	[15, 18]
miR-133a	Down	Repress EGFR signaling by directly targeting IGF-1R, TGFR1, and EGFR	[25]
miR-133b	Down	Suppresses EGFR pathway signaling and enhances susceptibility to EGFR-TKI in lung cancer cells by directly targeting EGFR	[39]
miR-145	Down	Negatively regulates EGFR expression in lung cancer cells	[31]
miR-146a	Down	Inhibit EGFR in NSCLC cancer cells	[40, 41]
miR-146b-5p	Down	Suppressed EGFR expression in glioblastoma cell lines	[42]
miR-200	Down	Regulates EMT in anaplastic thyroid cancer cells and bladder cancer cells and reverses resistance of EGFR therapy	[43, 44]
miR-206	Down	Suppresses EGFR signaling in squamous lung cancer cells by directly targeting EGFR and MET	[45]
miR-542-5p, 1203, 1237, 541, 1911	Down	Downregulates EGFR in human lung cancer cells	[20, 24]
miR-21	Up	Regulate the EGFR/AKT pathway in a PTEN independent manner	[46]
miR-24	Up	Activates EGFR signaling by targeting PTPN9 and PTPRF	[47]
miR-25	Up	Upregulated in EGFR positive lung cancer	[23]
miR-214	Up	Regulate acquired resistance to EGFR-TKIs in cancer cells through a PTEN/AKT signaling pathway	[48]