Emerging Roles of MicroRNAs in EGFR-Targeted Therapies for Lung Cancer

Table 3

MicroRNAs regulate chemoresistance in lung cancer.

MicroRNA(s)	Regulation	Agent	Target(s)	Reference(s)
let-7	Down	Erlotinib	Hedgehog	[52]
miR-34	Down	Gefitinib	c-MET/HGF	[51]
miR-103	Down	Gefitinib	PKC-	[32]
miR-128b	Down	Gefitinib	EGFR	[15]
miR-138-5p	Down	Gefitinib	GPR124	[53]
miR-145	Down	TKIs	ERK, AKT, OCT4, c-MYC, EGFR, and NUDT1	[31, 54]
miR-146a	Down	TKIs	EGFR and NF-B	[40]
miR-147	Down	Gefitinib	ZEB1 and AKT	[55]
miR-200	Down	Erlotinib	Hedgehog, MIG6, and TGF1	[52, 56, 57]
miR-203	Down	Gefitinib	SRC	[32]
miR-424	Down	TKIs	Not applicable	[15]
miR-548b	Down	TKIs	CCNB1	[58]
miR-7	Up	TKIs	EGFR, RAF1, and IRS-1	[21, 59, 60]
miR-21	Up	Gefitinib	PTEN, MDR1, Bcl-2, and PDCD4	[33]
miR-30b/30c	Up	Gefitinib	BIM	[32]
miR-126	Up	Gefitinib	AKT, EGFL7, PI3KR2, ERK, CRK, and VEGF	[54]
miR-134/487b/655 cluster	Up	Gefitinib	MAGI2	[49]
miR-221/222	Up	Gefitinib	APAF-1	[32]
miR-214	Up	TKIs	PTEN, MAPK, and p38	[46]
miR-374a	Up	TKIs	Wnt5a	[58]