BioMed Research International / 2015 / Article / Tab 1

Research Article

Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?

Table 1

Measurement of Lp-PLA2, intima media thickness (IMT), flow mediated dilatation (FMD), traditional risk factors for cardiovascular disease (CVD), and disease activity in patients with early rheumatoid arthritis (RA) and in age- and sex-matched controls evaluated both at baseline (T0) and after 5 years (T5). Data are expressed as mean value (standard deviation).

RA () Controls ()
At T0At T5At T0At T5

Lp-PLA2, ng/mL144.0 (41.7)154.6 132.0 (37.8)148.1
Intima media thickness, mm0.52 (0.13)0.58 0.54 (0.13)0.60
Endothelium dependent flow mediated vasodilatation, %109.2 (4.7)107.0 107.2 (4.5)106.0 (4.6)
Systolic blood pressure, mmHg123.5 (14.4)126.3 117.7 (11.3)124.1
Cholesterol, mmol/L5.5 (0.9)5.3 (1.0)5.3 (1.1)5.6 (1.1)
HDL, mmol/L1.6 (0.5)1.6 (0.5)1.5 (0.4)1.7 (0.5)
Non-HDL-cholesterol, mmol/L3.9 (0.9)3.7 (1.0)3.9 (1.1)3.9 (1.1)
Triglycerides, mmol/L1.3 (0.5)1.2 (0.5)1.1 (0.3)1.0 (0.5)
BMI, kg/m225.8 (4.0)25.7 (4.5)25.1 (4.9)25.2 (4.2)
CRP, mg/L11.9 (10.8)7.7 n/an/a
DAS283.5 (1.4)3.1 (1.5)n/an/a

value < 0.05; value < 0.01; value < 0.0001; p value = 0.061; all values compared with T0.
Lp-PLA2: lipoprotein-associated phospholipase A2; HDL: high-density lipoproteins; BMI: body mass index; CRP: C-reactive protein; DAS28: disease activity score for 28-joint count.