A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice

Figure 3

Effects of vitamin C on MDA content, serum NO level, iNOS protein expression, and mitochondrial membrane potential (Δψm) of lung tissue in restraint-stressed mice after infection. (a) MAD contents in lung tissue; (b) NO level in serum; (c) iNOS protein expression intensity to β-actin of lung tissues; (d) mitochondrial membrane potential expressed as the ratio of fluorescent intensity to normal group. Kunming mice were administered with vitamin C (125 and 250 mg/kg) for 7 consecutive days starting 1 day before restraint stress. Mice were fixed in a restraint cage for 18 h and sacrificed 4 days later. The results represented the mean ± SE of values obtained from 10 mice in each group. N, normal; V, virus; M, model; R, ribavirin; E, edaravone; Vc-L, vitamin C-low dosage; Vc-H, vitamin C-high dosage. Significant differences from the normal group at , , the virus group at , and model group at , .

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