A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice

Figure 7

Effect of vitamin C on MAVS, IRF3, and NF-κB p65 in lung tissues of restraint-stressed mice after infection. MAVS, IRF3, and NF-κB p65 mRNA expression in lung tissues from 10 mice in each group were determined by RT-PCR and normalized by 18S. MAVS, IRF3, and NF-κB p65 protein levels were determined by western blotting and normalized by β-actin. N, normal; V, virus; M, model; R, ribavirin; E, edaravone; Vc-L, vitamin C-low dosage; Vc-H, vitamin C-high dosage. Significant difference from the normal group at , , from the virus group at , , and from the model group at , .

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