Well-Designed Bone-Seeking Radiolabeled Compounds for Diagnosis and Therapy of Bone Metastases

Figure 5

⁶⁸Ga-BPAMD was injected intravenously into a patient with extensive bone metastases of prostate cancer. ⁶⁸Ga-BPAMD [maximum intensity projection (MIP) 50 min after injection (p.i.), 462 MBq] revealed intense accumulation in multiple osteoblastic lesions in the central skeleton, ribs, and proximal extremities: (a) = coronal PET, (b) = sagittal PET/CT. For comparison, (c) shows ¹⁸F-fluoride PET (sagittal, MIP 90 min p.i., 270 MBq). With kind permission from Springer Science+Business Media: Eur J Nucl Med Mol Imaging, PET/CT imaging of osteoblastic bone metastases with ⁶⁸Ga-bisphosphonates: first human study, 37, 2010, 834, Fellner et al.

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