The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
Table 3
Estimated marginal means (95% CI) of the lipid profile based upon the genotypes of the studied SNPs in all study subjects.
TC
TG
HDL-C
LDL-C
rs599839 A>G-genotypes
AA
5.29 (3.92–6.81)
3.02 (0.85–6.09)
1.44 (0.84–1.93)
3.44 (2.92–3.90)
AG+GG
5.06 (4.21–5.92)
2.87 (0.75–6.72)
1.48 (0.99–1.86)
2.92 (2.27–3.65)
GG
4.13 (3.62–5.05)
2.68 (0.46–7.58)
1.58 (0.89–2.72)
2.58 (2.31–3.39)
AA+AG
4.53 (3.77–5.38)
3.49 (0.78–7.66)
1.46 (0.78–1.91)
2.74 (2.00–3.47)
AG
4.66 (3.17–5.38)
3.08 (0.79–7.63)
1.52 (0.78–2.26)
2.68 (2.21–3.77)
value for rs599839 genotypes
GG vs. AA+AG
0.180
0.905
0.731
0.638
AG+GG vs. AA
0.210
0.604
0.630
0.050
GG vs. AA
0.041
0.628
0.751
0.026
rs646776 A>G-genotypes
TT
4.62 (4.07–5.35)
6.69 (0.97–12.47)
1.15 (0.44–1.85)
2.93 (2.37–3.47)
TC+CC
4.46 (3.61–5.31)
2.42 (1.12–6.24)
2.04 (0.48–2.36)
2.79 (1.87–3.69)
CC
4.69 (3.38–6.02)
2.30 (1.34–12.31)
2.16 (1.54–2.78)
2.52 (1.73–3.30)
TC
4.52 (3.02–6.04)
3.54 (0.72–8.09)
1.44 (1.21–2.77)
2.53 (1.74–3.33)
TT+TC
4.61 (3.37–5.98)
4.52 (0.88–9.29)
1.36 (0.95–1.76)
2.64 (1.98–3.30)
value for rs646776 genotypes
TC+CC vs. TT
0.590
0.250
0.041
0.272
CC vs. TT+TC
0.972
0.087
0.021
0.252
CC vs. TT
0.906
0.018
0.004
0.427
rs4970834 C>T-genotypes
CC
4.92 (4.12–5.72)
3.11 (1.18–8.16)
1.51 (0.94–2.07)
3.32 (2.48–4.15)
CT+TT
4.39 (3.66–5.13)
2.78 (1.69–7.69)
1.44 (1.02–1.87)
2.99 (2.36–3.63)
TT
4.19 (3.85–5.54)
2.42 (0.97–6.56)
1.38 (0.79–1.97)
2.74 (2.19–3.29)
CT
4.62 (3.45–5.81)
2.64 (0.77–6.98)
1.48 (0.92–1.98)
3.10 (2.45–3.75)
CC+CT
4.75 (3.62–5.87)
2.87 (1.02–7.15)
1.46 (0.86–2.01)
3.01 (2.47–3.73)
value for rs4970834 genotypes
CC vs. CT+TT
0.311
0.845
0.757
0.792
TT vs. CT+CC
0.880
0.852
0.657
0.165
CC vs. TT
0.752
0.912
0.812
0.386
Analysis of variance by general linear model with adjusted age, gender, BMI, type 2 diabetes, smoking, hypertension, and lipid-lowering therapy. LDL-C: low-density lipoprotein cholesterol and HDL-C: high-density lipoprotein cholesterol. Two-tailed value is significant at <0.05.
