The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients

Table 6

Estimated haplotype frequency of the rs599839, rs646776, and rs4970834 polymorphisms in chromosomal locus 1p13.3 and its associations with the severity of coronary artery lesion in coronary artery disease (CAD) patients for significant stenosis versus nonsignificant stenosis outcome.

rs599839		rs4970834		rs646776		Haplotype	EM frequency; ≥50%	EM frequency; <50%	Adjusted OR,; 95% Cl	value
A	G	C	T	T	C
A	G	C	T	T	C	ATC	0.284	0.364	0.69; (0.46–1.05)	0.090
A	G	C	T	T	C	GTC	0.295	0.178	0.54; (0.21–0.96)	0.005
A	G	C	T	T	C	ACC	0.186	0.219	0.82; (0.51–1.32)	0.410
A	G	C	T	T	C	GCC	0.093	0.135	0.66; (0.36–1.21)	0.172
A	G	C	T	T	C	GCT	0.061	0.034	1.85; (0.70–4.89)	0.208
A	G	C	T	T	C	ATT	0.043	0.058	0.73; (0.30–1.74)	0.471
A	G	C	T	T	C	GTT	0.028	0.007	4.00; (0.58–27.57)	0.128

Data are presented as frequency for severity of coronary artery lesion in CAD patients with significant lesion (≥50%) versus insignificant stenosis (<50%) for each haplotype with the odds ratio, lower and upper 95% confidence intervals, and value. The data were analyzed by logistic regression analysis. ORs were adjusted for age, gender, BMI, type 2 diabetes, smoking, hypertension, and lipid-lowering therapy. Two-tailed value is significant <0.05.