The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients

Table 7

Effect of interaction between serum LDL-C and genetic variants at Ip13.3 locus on the risk of significant coronary stenosis in ACS patients.

SNP	Model	OR	95% CI	Synergy index () with 95% CI
	High LDL	1.27	0.68–1.97
rs599839	AG+GG vs. AA	0.59	0.34–1.02
	Both	0.87	0.36–2.13	0.41 (0.15–1.14)
	High LDL	1.27	0.68–1.97
rs646776	TC+CC vs. TT	0.62	0.27–1.43
	Both	1.01	0.26–3.95	0.57 (0.21–1.54)
	High LDL	1.27	0.68–1.97
rs4970834	CT+TT vs. CC	0.98	0.57–1.68
	Both	1.04	0.45–2.40	0.43 (0.15–1.27)

Data are presented by OR and 95 % CI. Both means high LDL and genetic model effect on risk of stenosis, calculated by logistic regression analysis (see stat analysis). Synergy index () with 95% CI is biological measure of the interaction between two effects on one biological parameter, and if below 1 means it is antagonistic and if above 1 suggests synergistic or additive.