CD40 Ligand Deficient C57BL/6 Mouse Is a Potential Surrogate Model of Human X-Linked Hyper IgM (X-HIGM) Syndrome for Characterizing Immune Responses against Pathogens
Basal Ig isotypes sera concentrations of WT and C57-CD40L−/− mice. (a) Basal IgM, IgG, and IgA concentrations. Ig concentrations were determined by extrapolation from a standard curve. The total mean IgM concentration was similar among mice strains. Total IgG and IgA serum concentrations of C57-CD40L−/− were significantly lower than concentrations of WT mice. (b) Basal IgG subclasses sera concentrations. IgG3 levels were essentially identical between the two groups and all other subclasses concentrations were significantly higher in WT than in CD40L deficient mice. Mean comparisons were done by Mann-Whitney -test. WT = wild type.