Inhibition of Osteoclast Activation by Phloretin through Disturbing αvβ3 Integrin-c-Src Pathway

Figure 1

Chemical structure of phloretin (a), plasma osteocalcin level (b), and induction of trabecular collagen formation (c) in ovariectomized (OVX) mouse femoral bone tissues. Plasma osteocalcin level was measured by using an ELISA kit in OVX mice orally administrated with 10 mg/kg phloretin daily for 8 weeks. Plasma osteocalcin levels (mean ± SEM, ) in bar graphs not sharing a letter indicate significant difference at . Picrosirius red staining was conducted for detecting trabecular bone collagen. The black arrows indicate the depletion of collagen in trabecular bones of the epiphysis. Representative images were visualized under light microscopy. Magnification: 40-fold.

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