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BioMed Research International
Volume 2015, Article ID 683640, 7 pages
Clinical Study

Comparison of the Effect of Vaginal Zataria multiflora Cream and Oral Metronidazole Pill on Results of Treatments for Vaginal Infections including Trichomoniasis and Bacterial Vaginosis in Women of Reproductive Age

1Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz 7193613119, Iran
2Dezful Health Center, Dezful University of Medical Science, Dezful 7461715765, Iran
3Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz 713451978, Iran
4Department of Statistics, Health Faculty, Shiraz University of Medical Sciences, Shiraz 713451978, Iran
5Clinical Trials Department, Barij Essence Company, P.O. Box 1178, Kashan, Iran

Received 13 January 2015; Accepted 9 June 2015

Academic Editor: Gail B. Mahady

Copyright © 2015 Khadijeh Abdali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Effect of Zataria multiflora on bacterial vaginosis and Trichomonas vaginalis is shown in vivo and in vitro. We compare the effectiveness of Zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including Trichomonas and bacterial vaginosis; these infections occur simultaneously. The study included 420 women with bacterial vaginosis, Trichomonas vaginalis, or both infections together, who were randomly divided into six groups. Criteria for diagnosis were wet smear and Gram stain. Vaginal Zataria multiflora cream and placebo pill were administered to the experiment groups; the control group received oral metronidazole pill and vaginal placebo cream. Comparison of the clinical symptoms showed no significant difference in all three vaginitis groups receiving metronidazole pill and vaginal Zataria multiflora cream. However, comparison of the wet smear test results was significant in patients with trichomoniasis and bacterial vaginosis associated with trichomoniasis in the two treatment groups ( and ). Vaginal Zataria multiflora cream had the same effect of oral metronidazole tablets in improving clinical symptoms of all three vaginitis groups, as well as the treatment for bacterial vaginosis. It can be used as a drug for treatment of bacterial vaginosis and elimination of clinical symptoms of Trichomonas vaginitis.