Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β-Globin Gene with the IVSI-6 Thalassemia Mutation

Figure 5

Fluorescence in situ hybridization results on metaphase (a, d, e, f, h) or G1 (b) and G2 (c, g, i) interphase nuclei of homozygous (a–e), hemizygous (f-g), and wild-type mice (h-i). The arrows indicate the integration site of the transgene, located in mouse chromosome 7.

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