Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines

Figure 2

(a) Intense, diffuse cytoplasmic serglycin staining in a poorly differentiated colon adenocarcinoma. (b) Weak immunopositivity for serglycin in a well-differentiated adenocarcinoma, arising from an adenoma. (c) Moderately differentiated colon adenocarcinoma displaying strong immunoreactivity for serglycin. (d) Lager magnification showing that plasma cells, lymphocytes, and stromal cells of the invasive front are positive for serglycin. (e) Normal colon glands exhibit moderate cytoplasmic levels for serglycin. Note that muscularis mucosa (asterisk) is positive for serglycin, whereas staining is weak in plasma cells, lymphocytes, and stromal cells of the lamina propria (arrow). (a, b, c, e) Original magnification 20x; (d) original magnification 40x.