Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines

Figure 5

(a) A moderately differentiated squamous cell lung carcinoma displaying strong cytoplasmic serglycin immunoreactivity. Note that stroma and chronic inflammation cells are also intensively positive for serglycin, primarily at the invasive fronts (box). (b) A moderately differentiated lung adenocarcinoma that shows strong serglycin immunoexpression. (c) Serglycin immunopositivity in a low-grade bronchoalveolar adenocarcinoma. (d) Note that in this case of large cell undifferentiated lung carcinoma serglycin mainly displays cytoplasmic, granular immunoreactivity; however, it also displays nuclear (arrowheads) and the cell membranous (arrows) localization. (e and f) In normal lung sections, serglycin is detected in the epithelium of bronchioles as well as in alveolar macrophages and pneumocytes. Original magnifications 20x.

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