Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters
Table 2
Oxidative, neurohormonal, inflammatory, and nutritional parameters of heart failure patients and healthy Controls.
Controls ()
NYHA Class II ()
NYHA Class III ()
NYHA Class IV ()
Oxidative
MPO activity (mU/min)
10.5 (2.5–26.4)
21.9 (4.8–83.1)
23.5 (2.5–102.5)
30.1 (12.2–85.2)
Ceruloplasmin (nmol/L)
2176 ± 453
2153 ± 426
2508 ± 489†
2662 ± 560
FeOx I activity (UI/L)
442 ± 128
437 ± 142
367 ± 151
336 ± 110
Nitrated proteins (nmol/L)
274 ± 69
314 ± 75
402 ± 97
428 ± 85
Malondialdehyde (umol/L)
0.25 ± 0.09
0.32 ± 0.09
0.43 ± 0.13
0.47 ± 0.12
15-F2t-isoprostane, pg/mL
56 ± 30
91 ± 30
128 ± 48
140 ± 46
Neurohormonal
Norepinephrine (pg/mL)
256 ± 76
266 ± 70
363 ± 101
621 ± 220
BNP (pg/mL)
37 (11–62)
48 (12–196)
183 (19–459)
283 (105–620)
PRA, ng/mL/hr
1.12 ± 0.86
1.58 ± 0.81
2.41 ± 1.24
4.69 ± 2.22
Aldosterone, pg/mL
169 ± 79
177 ± 94
247 ± 135
295 ± 110
Inflammatory and nutritional
hsCRP (mg/dL)
0.78 (0.12–4.56)
0.82 (0.17–9.30)
1.90 (0.66–36.16)
7.22 (1.49–44.31)
Albumin (g/dL)
3.9 ± 0.5
3.9 ± 0.5
3.7 ± 0.6
3.1 ± 0.7
Prealbumin, mg/dL
29.5 ± 5.3
29.8 ± 6.3
26.5 ± 7.7
20.2 ± 8.1
Total cholesterol (mg/dL)
194 ± 20
216 ± 34
210 ± 42
202 ± 36
Data are reported as mean ± SD or median (range) depending on the distribution of data; BNP: B type natriuretic peptide; hsCRP: high sensitivity C-reactive protein; PRA: plasma renin activity; MPO: Myeloperoxidase-related chlorinating activity; FeOx I: ferroxidase I activity; indicates less than 0.05 versus Controls, † versus NYHA II, and # versus NYHA III.
