Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma
Table 3
The frequency of BRAF and RAS gene mutations in 187 follicular variants of papillary carcinoma.
Nucleotide change
Amino acid change
Number of mutated cases (%)
BRAF codon 600
c.1799T>A
p.V600E
56 (29.9)
c.1799_1801delTGA
p.V600_K601del3*
1 (0.5)
BRAF codon 601
c.1801A>G
p.K601E
11 (5.9)
NRAS codon 12
c.34G>A
p.G12S
1 (0.5)
NRAS codon 61
c.182A>G
p.Q61R
34 (18.2)
c.181C>A
p.Q61K
5 (2.7)
HRAS codon 61
c.182A>G
p.Q61R
7 (3.7)
c.181C>A
p.Q61K
6 (3.2)
c.183G>T
p.Q61H
1 (0.5)
KRAS codon 61
c.182A>G
p.Q61R
8 (4.3)
c.181C>A
p.Q61H
1 (0.5)
c.180_181TC>AA
p.Q61K
1 (0.5)
No mutation
55 (29.4)
Total
187
This rare deletion mutation in the BRAF gene (c.1799_1801delTGA) converts codon 600GTG (valine) and 601AAA (lysine) to a new single codon GAA (glutamic acid).
