Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities

Figure 1

Representative chromatograms of cefixime and impurities. (a) Total ion chromatogram of cefixime capsule (TIC), (b) extracted ion chromatogram (EIC) at m/z 454; (c) EIC at m/z 472; (d) EIC exclude m/z 454. 0, cefixime; 1, m/z 454; 2, 3, m/z 472; 4, m/z 442; 5, 6, m/z 428; 7, m/z 468; 8, 9, m/z 486; 10, m/z 442; 11, m/z 482; and 12, 13, m/z 500. The data was recorded under positive mode with an electrospray ionization source (ESI). The scan range is between 100 amu and 800 amu.

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