PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis

Figure 3

Model of regulation the Topo-1 binding protein- (TOPORS-) mediated degradation of p53 by PLK-1 in the response of long time cell cycle arrest. PLK-1-mediated phosphorylation of TOPORS at Ser-718, leads the ubiquitination of p53 to proteasomal degradation. PLK-1 mediated phosphorylation of GTSE1 inactivates the tumor suppressor gene p53. Consequently, PLK-1-mediated inactivation and/or degradation of p53 causes the tumorigenesis.