Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity

Table 1

Characteristics of main DAISY cohort by IA status ( = 2,528).

Characteristic	Number (%)		value
	Developed IA ( = 169)	Did not develop IA ( = 2,359)
Age, median (IQR), y	6.0 (6.6)^1	9.0 (10.9)^2	<0.0001
HLA-DR3/4, DQB1^*0302 genotype	63 (37%)	435 (18%)	<0.0001
First-degree relative with T1D	100 (59%)	1019 (43%)	<0.0001
Female	88 (52%)	1126 (48%)	0.28
Race/ethnicity, non-Hispanic white	132 (78%)	1690 (72%)	0.10
Maternal age, mean (SD), y	30.3 (5.8)	29.8 (5.7)	0.25

DAISY, Diabetes Autoimmunity Study in the Young; HLA, human leukocyte antigen; IA, islet autoimmunity; T1D, type 1 diabetes.
¹Age at first IA positive visit.
²Age at last follow-up.