Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity

Table 3

Assessment of the proportional hazards assumption in DAISY cohort.

Characteristic	Supremum test	Schoenfeld residuals global	Schoenfeld residuals individual covariate	Restricted cubic splines association	Restricted cubic splines nonconstant	Restricted cubic splines nonlinear
Non-Hispanic white ethnicity^1	0.01	0.02	0.01^2	0.03^3	0.01^3	0.62^3
Maternal age^1	0.01	0.01	0.003^4	0.003^5	0.001^5	0.03^5
Erythrocyte membrane n-3 fatty acid levels^1	N/A	N/A	N/A	0.001^6	0.001^6	0.17

DAISY, Diabetes Autoimmunity Study in the Young; HLA, human leukocyte antigen; T1D, type 1 diabetes.
N/A: statistical tests were not performed based on the inability to reject the null hypothesis of the prior test in the hierarchical structure.
¹Adjusted for HLA-DR3/4, DQB1^*0302 genotype and first-degree relative with T1D.
²Figure 2(a).
³Figure 3(a).
⁴Figure 2(b).
⁵Figure 3(b).
⁶Figure 4.