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BioMed Research International
Volume 2015, Article ID 708563, 11 pages
http://dx.doi.org/10.1155/2015/708563
Research Article

Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data

1Department of Precision Medicine, Oncology Research Unit, Pfizer Inc., Pearl River, NY 10965, USA
2Department of Pathology, Columbia University, New York, NY 10032, USA
3Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

Received 17 December 2014; Revised 6 March 2015; Accepted 9 March 2015

Academic Editor: Dapeng Hao

Copyright © 2015 Jiyang Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In the supplementary files, we provide details about the top differentially-expressed genes induced by anti-cancer drugs (Table S1), and their enrichment in pro- or anti- apoptotic gene sets (Figure S1-2, Table S2). We also provide details of literature-identified interactions among the 13 selected candidate apoptotic genes (Table S3).

  1. Supplementary Material